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GATE BT Syllabus 2027 Revised PDF (Out) - Biotechnology Topic Wise Weightage
GATE BT Syllabus 2027 (BT) - The IIT Madras has announced the revised GATE 2027 Biotechnology syllabus on the official website, gate2027.iitm.ac.in. Candidates can access the GATE BT syllabus 2027 pdf link on this page. The biotechnology syllabus for GATE 2027 consists of topics from various sections like General Aptitude, Engineering Mathematics, General Biology, Genetics, and Cellular and Molecular Biology. Fundamentals of Biological Engineering, Bioprocess Engineering, Process Biotechnology, and others. Candidates should check the latest GATE Biotechnology syllabus before starting their preparation to understand the exam pattern and topic-wise weightage. Candidates can check the GATE syllabus PDF here in this article. The GATE entrance exam will be held on February 6, 7, 13, 14, 20 & 21, 2027.
Direct link to download the GATE 2027 Biotechnology syllabus
Live | Oct 4, 2026 | 8:11 PM IST
This Story also Contains
- GATE BT Syllabus 2027- Download PDF Here
- GATE Biotechnology 2027 Syllabus for Engineering Mathematics
- GATE 2027 Biotechnology Syllabus for General Biology
- GATE Biotechnology Syllabus for Genetics, Cellular and Molecular Biology 2027
- GATE Biotechnology 2027 Syllabus for Fundamentals of Biological Engineering
- GATE 2027 BT Syllabus for Plant, Animal, and Microbial Biotechnology
- GATE 2027 BT Syllabus for Recombinant DNA Technology and Other Tools
Candidates are advised to check the GATE exam pattern along with the syllabus. The GATE exam will be conducted for three hours. Along with the GATE Biotechnology syllabus, candidates must check the exam pattern to plan their preparation. Read the article for the GATE Biotechnology syllabus 2027.
GATE BT Syllabus 2027- Download PDF Here
IIT Madras has published the syllabus of GATE Biotechnology 2027 online. Candidates can check the complete syllabus on the official website. Students can check the detailed GATE 2027 BT syllabus in the table below.
GATE BT Syllabus 2027 for General Aptitude (GA)
| Chapters | Topics |
|---|---|
| GATE GA syllabus for Verbal Aptitude |
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| GATE GA syllabus for Quantitative Aptitude |
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| GATE GA syllabus for Analytical Aptitude |
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| GATE GA syllabus for Spatial Aptitude |
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GATE Biotechnology 2027 Syllabus for Engineering Mathematics
The Engineering Mathematics section in the GATE Biotechnology syllabus is common to many GATE engineering papers. It includes six important topics: Linear Algebra, Calculus, Differential Equations, Complex Variables, Probability and Statistics, and Numerical Methods. Candidates should have a clear understanding of these topics, as they form an important part of the exam. The detailed topics covered under each section are given below.
GATE BT Syllabus 2027 of Engineering Mathematics
| Sections | Topics |
|---|---|
| Linear Algebra | Matrices and determinants; Systems of linear equations; Eigen values and Eigen vectors. |
| Calculus | Multivariable calculus (limits, continuity, and differentiability); Partial derivatives, maxima and minima; Sequences and series; Test for convergence. Multivariable calculus: Gradient, divergence, and curl (for applications in fluid mechanics, transport processes, etc.). |
| Differential equations | Linear and nonlinear first order ODEs, higher order ODEs with constant coefficients; Cauchy’s and Euler’s equations; Laplace transforms. |
| Probability and Statistics | Mean, median, mode and standard deviation; Random variables; Poisson, normal and binomial distributions; Correlation and regression analysis; Bayesian Statistics. |
| Numerical Methods | Solution of linear and nonlinear algebraic equations; Integration by trapezoidal and Simpson’s rule; Single step method for differential equations. |
GATE 2027 Syllabus (All Subjects)
Download the GATE 2027 subject-wise syllabus PDF and prepare with the latest topics, section-wise weightage, and exam pattern for your chosen discipline.
Check NowGATE 2027 Biotechnology Syllabus for General Biology
The Biotechnology section of the GATE Biotechnology syllabus covers many important topics such as enzyme inhibition, competence, immunisation, genetics, molecular biology, bioprocess engineering, and more. Candidates should study all the topics carefully for preparation. The detailed list of topics is provided in the table below.
GATE BT General Biology Syllabus 2027
| Sections | Topics |
|---|---|
| Biochemistry | Biomolecules - structure and function; Biological membranes - structure, membrane channels and pumps, molecular motors, action potential and transport processes; Basic concepts and regulation of metabolism of carbohydrates, lipids, amino acids and nucleic acids; Metabolism: Regulation of metabolism of carbohydrates, lipids, amino acids, and nucleic acids; Detailed pathways like glycolysis, citric acid cycle, and fatty acid oxidation; Photosynthesis, respiration and electron transport chain; Enzymes - Classification, catalytic and regulatory strategies; Enzyme kinetics - Michaelis-Menten equation; Enzyme inhibition - competitive, noncompetitive and uncompetitive inhibition. |
| Microbiology | History of Microbiology, Bacterial classification and diversity; Bacterial cell wall composition, Gram positive and Gram-negative bacteria, Archea, Methods in microbiology; Microbial growth and nutrition; Operon- Lac, Trp and Ara operon, Nitrogen fixation;Microbial diseases and host-pathogen interactions; Antibiotics and antimicrobial resistance, Two-component system ( TCS), bacterial communication, Viruses - structure and classification. |
| Immunology | Primary and Secondary lymphoid organs; Innate immunity and Inflammation; Cytokines and Chemokines; Complement system; Effector responses: Cellular and Humoral Immunity; Molecular basis of Antibody diversity and function; Polyclonal and Monoclonal antibodies; T-cell and B-cell development; Memory responses; Major Histocompatibility complex (MHC); Antigen processing and presentation; Regulation of immune responses; Immune tolerance; Hypersensitivity; Autoimmunity and Immunodeficiency; Graft vs Host disease; Immunization and vaccines. |
GATE Biotechnology Syllabus for Genetics, Cellular and Molecular Biology 2027
The Genetics, Cellular and Molecular Biology section of the GATE Biotechnology Syllabus 2027 covers important topics such as genetic disorders, the structure of genes and chromosomes, the extracellular matrix, cell biology, and molecular biology. Applicants should prepare these topics thoroughly for the exam. The complete list of topics in syllabus is given below.
GATE Biotechnology Syllabus 2027 for Genetics, Cellular and Molecular Biology
| Sections | Topics |
|---|---|
| Genetics and Evolutionary Biology | Mendelian inheritance; Gene interaction; Complementation; Linkage, recombination and chromosome mapping; Extra chromosomal inheritance; Microbial genetics - transformation, transduction and conjugation; Bacterial gene mapping; Horizontal gene transfer and transposable elements; Chromosomal variation; Sex Determination; Genetic disorders; Population genetics; Epigenetics; Selection and inheritance; Adaptive and neutral evolution; Genetic drift; Species and speciation. |
| Cell Biology | Eukaryotic cell structure; Cell cycle and cell growth control; Cell-cell communication; Cell signalling and signal transduction; Non-cell autonomous cell signalling; Post-translational modifications; Protein trafficking; Cell death and autophagy; Extra-cellular matrix. |
| Molecular Biology | Molecular structure of genes and chromosomes; Mutations and mutagenesis;Regulation of gene expression; Nucleic acid - replication, transcription, splicing, translation and their regulatory mechanisms; Non-coding and micro RNA; RNA interference; DNA damage and repair |
GATE Biotechnology 2027 Syllabus for Fundamentals of Biological Engineering
The Fundamentals of Biological Engineering section of the GATE Biotechnology syllabus includes topics such as electron balance, Conduction and convective heat transfer, mixing in bioreactors, Laws of thermodynamics, and more. Let's check into a comprehensive description of the GATE BT syllabus:
GATE BT Fundamentals of Biological Engineering Syllabus 2027
| Sections | Topics |
|---|---|
| Bioreaction Engineering | Rate law, zero and first order kinetics; (More advanced kinetic models, including Michaelis-Menten kinetics for enzyme reactions. Inhibition kinetics: Competitive, non-competitive, and uncompetitive inhibition in enzyme catalysis); Ideal reactors - batch, mixed flow and plug flow; Enzyme immobilization, diffusion effects - Thiele modulus, effectiveness factor, Damkoehler number; Kinetics of cell growth, substrate utilization and product formation; Structured and unstructured models; Batch, fed-batch and continuous processes; Microbial and enzyme reactors; Optimization and scale up (Design and operation of microbial reactors (e.g., fermentation reactors) and enzyme reactors (e.g., immobilized enzyme systems); Case studies on the use of microbial reactors in large-scale production (e.g., antibiotics, biofuels). |
| Upstream and Downstream Processing | Media formulation and optimization; Sterilization of air and media; Filtration - membrane filtration, ultra filtration; Centrifugation - high speed and ultra; Cell disruption; Principles of chromatography - ion exchange, gel filtration, hydrophobic interaction, affinity, GC, HPLC and FPLC; Extraction, adsorption and drying; Measurement devices;Valves; First order and second order systems; Feedback and feed forward control; Types of controllers – proportional, derivative and integral control; Tuning of controllers. |
GATE 2027 BT Syllabus for Plant, Animal, and Microbial Biotechnology
The Plant, Animal, and Microbial Biotechnology section within the GATE Biotechnology syllabus encompasses a range of subjects, including methodology, Plastid transformation, Culture media composition and growth conditions, Biofuels, antibiotics, and more. Here are the significant topics covered in this section:
GATE Biotechnology Syllabus 2027 of Plant, Animal, and Microbial Biotechnology
| Section | Topics |
|---|---|
| Plants | Totipotency; Cell fate transition, direct and indirect organogenesis, regeneration of plants; Plant growth regulators and elicitors; Tissue culture and cell suspension culture system - methodology, kinetics of growth and nutrient optimization; Production of secondary metabolites; Hairy root culture; Plant products of industrial importance; Artificial seeds; Somaclonal variation; Protoplast, protoplast fusion - somatic hybrid and cybrid; Transgenic plants - direct and indirect methods of gene transfer techniques; Selection marker and reporter gene; Plastid transformation. |
| Animals | Culture media composition and growth conditions; Animal cell and tissue preservation;Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; Micro & macro- carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic animals; Knock-out and knock-in animals. |
| Microbes | Production of biomass and primary/secondary metabolites - Biofuels, bioplastics, industrial enzymes, antibiotics; Large scale production and purification of recombinant proteins and metabolites; Clinical-, food- and industrial- microbiology; Screening strategies for new products |
GATE 2027 BT Syllabus for Recombinant DNA Technology and Other Tools
The Recombinant DNA Technology and Other Tools in Biotechnology section of the GATE Biotechnology Syllabus 2027 covers important topics such as DNA libraries, RAPD, RFLP, enzymatic assays, gene prediction, UV, visible spectroscopy, and more. The complete list of topics is given below.
GATE BT Syllabus 2027 for Recombinant DNA Technology and Other Tools
| Section | Topics |
|---|---|
| Recombinant DNA Technology | Restriction and modification enzymes; Vectors - plasmids, bacteriophage and other viral vectors, cosmids, Ti plasmid, bacterial and yeast artificial chromosomes; Expression vectors; cDNA and genomic DNA library Gene isolation and cloning,strategies for production of recombinant proteins; Transposons and gene targeting, Recombination-based gene cloning. |
| Molecular tools | Polymerase chain reaction; DNA/RNA labelling and Sangers and next generation sequencing; Southern and northern blotting; In-situ hybridization; DNA fingerprinting, RAPD, RFLP; Site-directed mutagenesis; CRISPR-Cas; Biosensing and biosensors; DNA-protein and protein-protein interaction tools; Genomics and proteomics-based approaches. |
| Analytical tools | Principles of microscopy - light, electron, fluorescence and confocal; Principles ofspectroscopyUV, visible, fluorescence, CD, IR, FT-IR, MS, NMR; Electrophoresis; Micro- arrays; Enzymatic assays; Immunoassays - ELISA, RIA, immunohistochemistry; Immunoblotting; Flow cytometry; Whole genome and ChIP sequencing. |
| Computational tools | Bioinformatics resources and search tools; Sequence and structure databases; Sequence analysis - sequence file formats, scoring matrices, alignment, phylogeny; Genomics, proteomics, metabolomics; Gene prediction; Functional annotation; Secondary structure and 3D structure prediction; Knowledge discovery in biochemical databases; Metagenomics; Metabolic engineering and systems biology. |
GATE Biotechnology Exam Pattern 2027
The authority has released the GATE BT 2027 exam pattern online. Candidates can check the GATE 2027 exam pattern for Biotechnology to know the marking scheme, duration of the test, types of questions, and more. GATE BT question paper comprises 65 questions for 100 marks. The question paper has two sections - General Aptitude and Core Subject. GATE BT exam duration is of three hours.
GATE Biotechnology New Topics Added Syllabus
| Section | Topics |
|---|---|
| Section -1 | Gradient, Divergence, Curl, Applications in fluid mechanics/transport processes, Bayesian Statistics |
| Section -2 | Biochemistry - Detailed metabolic pathways, Glycolysis, Citric acid cycle, Fatty acid oxidation Microbiology- History of Microbiology, Bacterial cell wall composition, Gram-positive & Gram-negative bacteria, Archaea, Lac/Trp/Ara operons, Two-component system, Bacterial communication Immunology - Inflammation, Cytokines, Chemokines, Memory responses, Immunodeficiency |
| Section -3 | Genetics and Evolutionary Biology- Bacterial gene mapping, Sex determination Cell Biology - Non-cell autonomous cell signalling |
| Section - 4 | Bioreaction Engineering Upstream and Downstream Processing |
| Section -5 | Plants- Cell fate transition, Direct organogenesis |
| Section - 6 | Recombinant DNA technology: Recombination-based gene cloning, Molecular tools: DNA/RNA labelling and Sangers and next generation sequencing, DNA-protein and protein-protein interaction tools; Genomics and proteomics-based approaches. Analytical tools: |
Frequently Asked Questions (FAQs)
Q: How can I prepare for GATE 2027 Biotechnology?
A:
To prepare for GATE 2027 Biotechnology, candidates must focus on subject-specific preparation by using specialized books and practice materials.
Q: How many sections are there in GATE Biotech syllabus?
A:
The syllabus of GATE Biotechnology 2027 consists of a total of seven sections, including Engineering Mathematics and core Biotechnology-related subjects.
Q: What is the marking scheme for GATE syllabus biotechnology 2027?
A:
In the GATE Biotechnology 2027 exam, questions carry either 1 mark or 2 marks.
Q: Is the GATE Biotechnology Syllabus Updated Regularly?
A:
Yes, the GATE syllabus, including the Biotechnology section, is updated periodically to align with the evolving trends in the field. The updates ensure that the syllabus remains relevant and covers the latest advancements and concepts in biotechnology.
Q: Where can I find the detailed GATE Biotechnology syllabus for 2027?
A:
Aspirants can find the detailed GATE 2027 Biotechnology syllabus on the official website.
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